Originally developed to treat Type 2 diabetes, the GLP-1 medications were found to have an “interesting” side-effect: significant weight loss. This unexpected benefit led to further research and FDA approval for the use of Ozempic (as Wegovy) and Mounjaro (as Zepbound) in obesity and overweight management. The active ingredients in these medications are Semaglutide and Tirzepatide.

These medications are primarily administered as injections, using small needles that are placed superficially into fatty areas of the body. They interact with cell receptors in the pancreas, gastrointestinal tract, and other parts of the body. These medications are modified versions of peptide molecules that closely resemble structures produced by our bodies. They can delay the processing and emptying of food from the stomach, leading to feelings of early and long-lasting fullness after meals. They also influence brain centers to regulate and reduce cravings, which can help patients manage stress-eating and reward-eating behaviors, contributing to weight loss.

Extensive research on these medications has revealed that they have many other effects in our bodies that confer potential health benefits beyond weight loss. Wegovy has recently received FDA approval for use to lower the risk of nonfatal heart attacks, nonfatal strokes, and cardiovascular death (the so-called “MACE” risk) in high-risk adults who are overweight or obese. The GLP-1 medications appear to confer several other health benefits in patients who use them.

These medications cause patients to experience enhanced fullness and to decrease cravings for certain (usually unhealthy) foods, and sometimes for alcohol. These effects can help control hunger and emotional-eating tendencies; and for most users, result in decreased intake of kilocalories. When used responsibly in conjunction with healthy lifestyle changes – specifically reduced intake of calories (“eating less”) and eating a healthier diet, and incorporating regular exercise into patients’ daily activities – these medications can contribute to a healthy, sustainable plan to achieve lasting weight loss.

Enhancing Weight Management through Advanced Science
Medical weight loss injections leverage the latest advancements in medical science to support significant weight loss. These injections, often part of a comprehensive medical weight loss program, utilize medications that function similarly to naturally occurring hormones in the body. They are designed to regulate appetite and enhance metabolic health, which are crucial in managing obesity and associated health risks.

Mechanism of Action
The active agents in these injections mimic the effect of GLP-1 (glucagon-like peptide-1), a hormone that plays a vital role in appetite regulation and glucose metabolism. Here’s how they facilitate weight loss:

• Gastric Delay: By slowing down gastric emptying, these injections help you feel fuller longer after meals, reducing the urge to overeat.
• Appetite Suppression: They increase satiety and decrease hunger through direct action on the appetite centers in the brain, leading to a lower caloric intake.
• Blood Sugar Control: By inhibiting the release of glucagon — a hormone that raises blood glucose levels — these injections help stabilize blood sugar levels, which is especially beneficial for individuals with type 2 diabetes.